The the study of tissue maintenance and regeneration

The small-molecule
compounds on periodontal ligament stem cells (PDLSCs) are of great interest for the study of tissue
maintenance and regeneration as the PDLSCs is one of the tissues with the
highest turnover rate and remodeling capacity in the human body. In addition,
Some small-molecule compounds in Extracellular matrix (ECM) will induce development of
PDLSC-like cells form iPS cells.

The previous report to outline
the production of PDLSCs from iPS cells to iPS-NC-PDL cells acquired the proliferative
and differentiative properties of PDL cells and expressed markers typical of Mesenchymal
stem cell (MSCs), reported that ECM from PDL cells was the most efficient of
iPS-NC-PDL cells, with a characteristics similar to that of primary PDLSCs.
Although Collagen type I (COL1) and Periostin (POSTN) are the major ECM
proteins in PDL tissue, these proteins could not increase the expression of
PDL-related markers and insufficient to drive PDLSC-like differentiation of
iPS-NC cells, and fibronectin and laminin showed some increase, it was not as
efficient as the PDL. (Hamano et al., 2017)  Therefore, I would like to find

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1.      
Role small-molecule
compounds derivative in ECM produced by cultured human PDL cells in
differentiation of iPS cells to PDLSCs

2.      
Identification
of small molecule compounds in ECM induced of the differentiation
of iPS cells to PDLSCs

Some other small-molecule compounds in ECM could induce the differentiation of PDLSCs, The study revealed that ECM
growth factor such as Connective tissue growth
factor (CTGF) and Fibroblast growth factor 2 (FGF2) induce PDLSCs to differentiate towards a PDL-like tissue in a collagen gel microenvironment and might thus be suitable for
periodontal regeneration therapy. In addition, RGD-modified hydrogels maintained
cell viability, attachment and increased the mineralization of the encapsulated
DFCs, and thus could have potential applications in healing periodontal defects
by regenerating new bone and cementum.

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