The overall nasal carriage of S.aureus in the present study was 12%. This is supported by study carried out in India (14%) 10. However, lower than that of reported from Ethiopia, (28.8%) 13, Democratic Republic Congo (16.5%) 16, Gaza Strip (31.1%) 17 Pakistan (48%) 18, China (25.3%) 19 and Iran (25.7%) 20. The total prevalence of MRSA in this study was 5.78%. This was similar with results from 8, France (5.3%) 21, Asia (6.1%) 8 and Iran (5.3%) 20. However, it was lower compared with the study revealed in Ethiopia, Mekelle (14.1%) 22 and Dessie (12.7%) 13, Egypt (20%) 23, Nigeria (39.9%) 12, Gaza Strip (25.5%) 17 and Pakistan (13.95%) 18. On the other hand, our result was higher than study reported from and China (1.0%) 19. This variations of prevalence among different study areas might be due to difference in rate of patient admission, study period 22, microbiological methods (from sample size to culture media) antimicrobial policy, moreover, different levels of commitment to infection control measure among hospitals, and awareness of the health care worker about MRSA may contribute to the difference. In current study, MRSA carriage was relatively higher among nurses (7.8%) followed by doctors (7.7%). This is consistent with study conducted in Ethiopia, Dessie 13, Gaza Strip 17 and India 10. MRSA carriage was particularly high among surgical ward (17.1%) this result is comparable with corresponding study in Gaza Strip (35%) 17 and Dessie (35%) 13.This finding could be explained by the increased physical contact of nurses and doctors with patients and high workload in surgical wards. In this study, decontamination of hands was statistically significant with MRSA colonization. Health care workers rarely decontaminated their hands were high proportion to have MRSA colonization on their anterior nare than those who were decontaminated usually and always. This finding is in line to previous studies in America 7, France 21 and Taiwan 24. The transient hand carriage of the organisms on the hands of health care workers could account for the major mechanism for the auto-transmission from contaminated hand to nose.The present study, found that being diabetic patients was statistically associated with MRSA colonization. Health care workers with diabetic were high proportion to have MRSA colonization on their anterior nare. This was in line with studies from Tanzania 25 Iran 20, and Taiwan 26. This may be due to diabetic patients reduced immunity which fails to combat the pathogens 25.In the current study, there was no statistically significant of MRSA with educational status, hand washing habit, prior hospitalization, history of antibiotic treatment, and presence of chronic obstructive pulmonary disease in this study. This was in agreement with a result obtained in Ethiopia 13 and other studies conducted in other parts of the world 8, 20, and 27.