Statins and WAVE proteins expressed in different tissue

Statins are-3-hydroxy-3-methylglutaryl-coenzymeA
reductase (HMG-COAR) inhibitors lead to inhibit cholesterol synthesis and
reduction of the downstream intermediate products that involve in carcinogenesis such as farnesyl pyrophosphate
(FPP) and geranylgeranyl pyrophosphate (GGPP) .Statins include :- lovastatin ,
simvastatin ,atrovastatin ,flavastatin , pravastatin and rosuvastatin calcium. Statins
used as hypocholesterolemic drugs in treatment of dyslipidemia , prevention cardiovascular
disease, prevent development atherosclerosis , decrease low-density lipoprotein
(LDL) , stroke myocardial injury and mortality . There is multi-effect of
statins as anti-inflammatory effect and anti-cancer effect and reduce cancer
risk by  firstly ,  decrease level of cholesterol that tumor cells
need it in development and expansion . Secondly , prevent oncogenic proteins (Ras,Rho,Rac,
and Rab) activation . Statins reduce risk of gastric cancer, reduce cell
migration and colony forming of prostate cancer-3 cells in prostate cancer ,
pancreatic cancer , esophagus cancer , hepatocellular
carcinoma, lung cancer, colon cancer , colorectal cancer , improved survival in ovarian cancer and act as
anew possible therapy in breast cancer  , in DVT( Deep Vein Thrombosis)
and PE (Pulmonary embolism) patients statins have protective influence. Statins
inhibit angiogenesis , tumor growth , invasion and metastasis , induce apoptosis
,reduce adhesion ,E selectin and matrix metalloproteinase -9 (MMP-9).In CLL
patients statin and aspirin enhance cell apoptosis in addition statins improve
response in chemotherapy.Moreover , Statins reduce risk of hematological
malignancies ,f non-hodgkin lymphoma(NHL), multiple myeloma (MM) also induce
apoptosis in CLL ,ALL,AML , MM and IM-9 lymphoblast .Because  the anti-leukemic effect of statins.  

Wiskott-Aldrch Syndrom (WAS) is a rare X-linked
recessive disorder caused by mutations in the gene for the WAS protein (WASP). WAS
characterized by thrombocytopenia, small platelet size, autoimmunity and an
increased risk of malignancies. WASP family contain WASP protein and N-WASP
also WAVE proteins (WASP-family veprolin-homologous protein) family contain WAVE1,WAVE2
andWAVE3. WASP proteins present only in hematopoietic cell but the rest of WASP
family and WAVE proteins expressed in different tissue in addition
expressed  in the cytoplasm of hematopoietic
cells.WASP/WAVE proteins are scaffolds link upstream signals to activate actin-
related protein 2 and 3 complex (ARP2/3) via binding with
Veprolin/Cofilin/Acidic domain at  C terminus
leading to initiate polymerization of actin cytoskeleton that required for
other pathological modification like cell shap and morphology ,enhance
cytokines , cell motility and cancer progression and metastasis

We Will Write a Custom Essay Specifically
For You For Only $13.90/page!


order now
x

Hi!
I'm Isaac!

Would you like to get a custom essay? How about receiving a customized one?

Check it out