Research magnetic properties along with Fe3O4 in


Research Proposal





Treatment of the Dental Diseases using Nanozymes

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Proposal Submitted by:


Biomedical Engineer

Email: [email protected]


Nanotechnology field is currently area of intense scientific research. Nanotechnology produces materials of nano-scale, known as nanoparticles. Due to the small size (<100nm) and other advantages nanoparticles have attracted the researchers. Nanoparticles have very vast scope in the field of biomedical they are often used for drug delivery, tissue imaging, sensing of target molecules and various other purposes. Nanonzymes are artificial enzymes (nanoparticles) which can function as a natural enzyme. Nanozymes are being used for sensing, imaging, anti-biofouling and other purposes. Fe3O4 will be our main research element, Fe3O4 has the paramagnetic properties, we can use other nanoparticles having magnetic properties along with Fe3O4 in order to overrule the current on going dental problems such as periodontal-diseases. Introduction Over the past few decades, scientists have been developing artificial enzymes for a broad range of applications. Nanozymes have great applications in the field of medicine; nanozymes can serve as an antibacterial drug. Periodontal diseases are most common dental diseases, periodontal diseases are infections that damage the soft tissues of the teeth, they can occur in form of gums, periodontal ligament and alveolar bone, which result in teeth loss or other health problems, periodontal diseases can also cause the heart disease, according to a research it is estimated that 47% adults aged 30 years and older have some form of periodontal diseases. Researchers are developing the new and effective techniques using nanozymes in order to revolutionize the ancestral dental procedures 2. Background and Literature Review The nanozymes journey started in early 90s. However, the name "nanozyme" was invented by Flavio Manea and co-workers in 2004 1. In 2008, Hui Wei and Erkang Wang developed an iron oxide nanozyme based sensing platform for bioactive molecules (such as hydrogen peroxide and glucose). 3 From the past two decades, nanozymes are being investigated and examined in the health sector. With the increase of dental problems and due to expensive medical cares, researchers are working to develop reliable and cost-effective treatment procedures, such treatments will be performed using the nanozymes. Novel regime will revolutionize the medical field and treatment procedures and it will definitely help people to get rid of expensive and painful treatment procedures. Recently, nanozymes have been included in the broad range of oral products, most of the oral products are helping in remineralizing of early sub micrometer-sized enamel lesions and treatment of oral diseases in early age, use of such products have shown some promising applications in few oral problems. However, the treatment of larger visible cavities and other oral diseases with nanoparticles is still at the research stage. Efforts are made to treat the diseases at large scale using nanozymes 2. Methodology My paper will discuss how the Fe3O4 and other nanoparticles can be helpful in order to deal with the periodontal diseases. Furthermore, I will be investigating questions such as "How can we develop antibacterial drugs with the help of nanozymes to eliminate the oral biofilm?", "What would be the best nanoparticle elements to combine?" This paper will also discuss (if there are) "the negative effects of applied nanozymes on the health", "Effect of nanozymes on teeth after going through different environments". As this paper focuses on treatment of dental diseases using the nanozymes, I will mainly be utilizing the professor Hui Wei's lab. I will also rely on the professor Hui Wei's publications and the students working in the laboratory. As mentioned previously, my main research element will be the Fe3O4, whereas other general nanoparticles and nanoparticles with magnetic properties will also be investigated in order to overrule the periodontal diseases problem. Conclusions and Future Research Aspects Nanozymes have become the strong candidate to replace the natural enzymes. Despite the advantages of nanozymes, there are several challenges and problems because of their low activity as compared to natural enzymes. Although various types of surface-modified nanozymes have been developed using the nucleic acid and polymers to mimic nanozymes as natural enzymes, nanozymes can be applied to the (enamel) outer most layer of teeth if patients avoid brushing the teeth, however, the practical implementation is still lacking in wide areas of compatibility and stability. Periodontal diseases are not being treated with the nanozymes; this research work can help us in developing Fe3O4 contained nanoparticle to treat the biofilm and other periodontal diseases. Finally, the target will be the designing and development of the nanozymes which can be used practically for the diagnosing and treatment of the biofilm and other periodontal diseases. By performing above mentioned methods nanozymes can be widely used in abroad range of applications in the near future. References 


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