Prostate treatment there is always a chance of

Prostate cancer (PCa) is one of
the most common of genitourinary cancer in men and is the third leading cause
of cancer death in American men 1. Present treatment modalities for localized
PCa include radiation therapy, chemotherapy and or surgery.  However taking consideration of this
treatment there is always a chance of metastasis. Metastasize PCa is associated
with a significant morbidity and mortality.

 

AR signalling known to play a
critical role in the development of normal prostate, (Wen et al., 2015) is
modified/deregulated to promote cell survival and proliferation in PCa
(Lonergan and Tindall, 2011).

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Wen, S., Chang, H.-C., Tian,
J., Shang, Z., Niu, Y., Chang, C., 2015. Stromal androgen receptor roles in the
development of normal prostate, benign prostate hyperplasia, and prostate
cancer. Am. J. Pathol. 185, 293–301. http://dx.doi.org/10.1016/j.
ajpath.2014.10.012.

 

Lonergan, P.E., Tindall, D.J.,
2011. Androgen receptor signaling in prostate cancer development and
progression. J. Carcinog. 10, 20. http://dx.doi.org/10.4103/1477- 3163.83937.

 

 

 

Progression of PCa is initially
depends on Androgen signaling based on the androgen receptor (AR). Androgen
deprivation therapy is primary treatment modality for metastatic PCa that may
result in a decrease in androgen ligands and/or blocks the Androgen receptor
binding. However, these treatment methods may fail in due course that make the
scenario worse. Therefore, it is of needed to identify and/ OR developed new
agents that can kill or sensitize tumor cells with no toxicity to healthy
tissues and that would have the remarkable impact on current therapies and
treatment regimens.

Tetrandrine
(TET) is a bis-benzylisoquinoline and a calcium channel blocker isolated from
the Chinese herbs Stephania tetrandra S. Moore, has been used to variety of
diseases such as hypertension, arrhythmia, arthritis as well as in treatment of
silicosis (2), and accumulating evidence suggests that tetrandrine acts as a
strong anticancer agent on diverse cancers in vitro/in-vivo, including colon
(3,4), hepatoma (5), bladder (6), and lung cancer (7). The beneficial impact of
tetrandrine on tumor cell multidrug resistance (8), radiosensitization (9) and
angiogenesis (10) has also attracted a great deal of attention. Despite this
current studies, there is not much known about the effect of TET on prostate
cancer presently. And the underlying mechanism of action of TET on prostate
cancer has not yet been well elucidated and explored. Therefore, in the current
study, we investigated the possible mechanism of TET on the AR and AR regulated
gene transcriptional activity, stability and regulation, inhibitory effect on cell
proliferation, cell cycle arrest, and induction of apoptosis in human prostate
cancer cell lines viz. LNCaP and C4-2 B cells as well as in NOD/SCID mice LNCaP
& C4-2 xenograft model. The results from present studies showed that
TET-induces apoptosis in prostate cancer cells and that contributes to cell
death. This finding is supported by TUNEL assay in LNCaP Xenograft tumor
tissue. Furthermore, we demonstrate for the first time that transcriptional
activity of AR and AR regulated gene is downregulated by TET. Taken together,
our data suggest a novel finding that potentiates TET as the crucial treatment
regimen for the Prostate cancer.

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