Histopathological the Brenners tumour that they arise

description of the EOTs by immunohistochemistry.

EOTs are
primarily tumours of the ovary and they develop from the mullerian epithelium.
However, studies have doubted this origin, and just like the testes (a germ
cell organ) the ovary rarely have epithelial tumours but mostly the germ cell
tumours and stroma neoplasms. Hence the question arises: – “is there any true primary epithelial tumour of the ovary or the
observed epithelial tumours are secondary from drop-off from the fallopian
tube, endometriosis and endocervical epithelium and recently for the Brenners tumour
that they arise from the wathered cell nest of the mesovarium, mesosalpinx and
ovarian hilum”? (Dubeau, 2008),(Gilks et al., 2015),(Kuhn, Ayhan, Shih, Seidman, & Kurman, 2013) This question makes the
histological characteristic of EOTs insufficient for diagnosis and hence
emphasis on the need for a phenotypic and genotyping characterization to prove
their origin as primary ovarian tumour or metastatic epithelial tumours

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In this study we
characterized the EOTs using cytokeratin markers CK7 and CK20 and reporting a
positive cytoplasmic staining to be represented by >50% proportion of
intensely stain cells.   

The CK7/CK20
immunoprofile of the Serous EOTs showed consistency with other studies where
majority 92.1% showed consistent expression for CK7. This is consistent with
findings by Strickland et al where majority 97.5% of their studied EOTs had a
strong diffuse CK7 expression(Strickland & Parra-Herran, 2016). Two Serous
cystadenoma and a Serous carcinoma co-expressed CK7+/CK20+, this subtype of
Serous tumour may be a mixed cell type EOT with predominant Serous phenotype
which we intend to investigate further with other markers to determine if
related to the new Sero-Mucinous group of EOTs(Shappell, Riopel, Smith Sehdev, Ronnett, &
Kurman, 2002). One (1) Serous cystadenoma and 3
Serous carcinoma did not stain for CK7, this may be related to technical
challenges with epitope retrieval(Taylor, Shi, Barr, & Wu, 2006),(Werner, Chott, Fabiano, & Battifora, 2000),(Otali et al., 2009). 

The Mucinous EOTs
sub-category CK7/CK20 immuno profile in this study showed CK7+/CK20+ profile
display occurring in 37.5% of cases hence reflecting a true primary mucinous
EOT characteristic. The intestinal type Mucinous tumours determined by the
CK7/CK20 expression was 37.5% of cases while 25% were endocervical-like
Mucinous EOTs. This subcategory of endocervical like Mucinous tumour have been
further studied by some authors and found to be a mixed EOTs with Sero-Mucinous
or Endometrioid components (Lin, Lindner, Silverman, & Liu, 2008). Because of this diverse phenotypes of Mucinous
tumours, CK7


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